MICROBIAL INSPIRED THERAPEUTICS: THE INTERSECTION OF THE GUT MICROBIOME AND NEUROLOGICAL DISEASE
Scientific researchers and the medical community have been validating how alterations and irregularities in the gut microbiome influence CNS functions such as emotions, communication, and motor and autonomic function. This connection is resulting in the development of novel diagnostic, prophylactic and therapeutic pharmaceuticals. Our mission is rooted in the related cutting-edge research of our scientific co-founder Dr. Sarkis Mazmanian at Caltech. Dr. Mazmanian’s groundbreaking work established several key concepts in the biology of the gut-brain axis, its role in neurodegenerative diseases and neurodevelopmental disorders, and the basis of the influence of the gut microbiome in people with autism and Parkinson’s disease (PD). Based on this novel research, we are focused on providing Microbial Inspired Therapeutics research and development, medical applications, and pharmaceuticals.
The Microbiome Gut-Brain Axis: Highway for New Drug Targets
Enteric Nervous System
Diversified technical risk
> 10 trillion bacteria
~ 500 bacterial species
Gut bacteria ≈ total human cells
The gut-brain axis encompasses bidirectional communication between the gastrointestinal (GI) tract and the CNS. It is now well established that the gut micrombiome has a strong influence on this communication. This bidirection pathway is mediated via the autonomic nervous system, including: 1) the vagus nerve, which represents the main component of the parasympathetic nervous system, which oversees a vast array of crucial bodily functions, including control of mood, immune response, digestion, and heart rate; 2) the enteric nervous system, referred to by scientists as the ‘second brain,’ which consists of hundreds of millions of neurons that extend along the length of the digestive tract and communicates subtle changes within the GI tract to the brain; and 3) the immune system, a pathway that gut microbiota can alter messages to the brain by affecting immune cells and their responses to inflammation and infection.
Blazing a New Trail in the Treatment of Neurological Diseases and Disorders
Axial’s scientific focus on the microbiome gut-brain axis represents a transformative therapeutic approach that has potential to treat neurological diseases and disorders in ways never before possible. Using the microbiome as a source for new drug targets, we are developing and providing Microbial Inspired Therapeutics research related to gut-targeted, small molecule therapeutics with little to no systemic absorption.