Extensive peer-reviewed clinical and preclinical research

Axial’s scientific focus on the interface between the microbiome and the human body and novel therapeutic approach is supported by extensive peer-reviewed clinical and preclinical research.

Explore select publications below.

April 14, 2022

Commentary: Trust Your Gut, Lest Thou Be Anxious

Yunjin Lee, Jun R. Huh

February 14, 2022

Safety and target engagement of an oral small-molecule sequestrant in adolescents with autism spectrum disorder: an open-label phase 1b/2a trial

A. Stewart Campbell, Brittany D. Needham, Christopher R. Meyer, Joanna Tan, Mary Conrad, Gregory M. Preston, Federico Bolognani, Srinivas G. Rao, Helen Heussler, Rebecca Griffith, Adam J. Guastella, Amy C. Janes, Blaise Frederick, David H. Donabedian & Sarkis K. Mazmanian

February 14, 2022

A gut-derived metabolite alters brain activity and anxiety behaviour in mice

Brittany D. Needham, Masanori Funabashi, Mark D. Adame, Zhuo Wang, Joseph C. Boktor, Jillian Haney, Wei-Lu Wu, Claire Rabut, Mark S. Ladinsky, Son-Jong Hwang, Yumei Guo, Qiyun Zhu, Jessica A. Griffiths, Rob Knight, Pamela J. Bjorkman, Mikhail G. Shapiro, Daniel H. Geschwind, Daniel P. Holschneider, Michael A. Fischbach & Sarkis K. Mazmanian

February 14, 2022

Commentary: Targeting microbial metabolites to treat autism

Rochellys Diaz Heijtz, Pierre Gressens & Jonathan R. Swann

March 1, 2021

Plasma and Fecal Metabolite Profiles in Autism Spectrum Disorder

Brittany D Needham, Mark D Adame, Gloria Serena, Destanie R Rose, Gregory M Preston, Mary C Conrad, A Stewart Campbell, David H Donabedian, Alessio Fasano, Paul Ashwood, Sarkis K Mazmanian

October 16, 2020

Gut microbial molecules in behavioural and neurodegenerative conditions

Brittany D Needham, Rima Kaddurah-Daouk, Sarkis K Mazmanian

February 11, 2020

A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice

Timothy R Sampson, Collin Challis, Neha Jain, Anastasiya Moiseyenko, Mark S Ladinsky, Gauri G Shastri, Taren Thron, Brittany D Needham, Istvan Horvath, Justine W Debelius, Stefan Janssen, Rob Knight, Pernilla Wittung-Stafshede, Viviana Gradinaru, Matthew Chapman, Sarkis K Mazmanian

May 13, 2015

Control of brain development, function, and behavior by the microbiome

Timothy R Sampson, Sarkis K Mazmanian

May 13, 2015

The Central Nervous System and the Gut Microbiome

Gil Sharon, Timothy R Sampson, Daniel H Geschwind, Sarkis K Mazmanian

December 19, 2013

Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders

Elaine Y Hsiao, Sara W McBride, Sophia Hsien, Gil Sharon, Embriette R Hyde, Tyler McCue, Julian A Codelli, Janet Chow, Sarah E Reisman, Joseph F Petrosino, Paul H Patterson, Sarkis K Mazmanian