Extensive peer-reviewed clinical and preclinical research
Axial’s scientific focus on the interface between the microbiome and the human body and novel therapeutic approach is supported by extensive peer-reviewed clinical and preclinical research.
Explore select publications below.
April 14, 2022
Commentary: Trust Your Gut, Lest Thou Be Anxious
Yunjin Lee, Jun R. Huh
February 14, 2022
Safety and target engagement of an oral small-molecule sequestrant in adolescents with autism spectrum disorder: an open-label phase 1b/2a trial
A. Stewart Campbell, Brittany D. Needham, Christopher R. Meyer, Joanna Tan, Mary Conrad, Gregory M. Preston, Federico Bolognani, Srinivas G. Rao, Helen Heussler, Rebecca Griffith, Adam J. Guastella, Amy C. Janes, Blaise Frederick, David H. Donabedian & Sarkis K. Mazmanian
February 14, 2022
A gut-derived metabolite alters brain activity and anxiety behaviour in mice
Brittany D. Needham, Masanori Funabashi, Mark D. Adame, Zhuo Wang, Joseph C. Boktor, Jillian Haney, Wei-Lu Wu, Claire Rabut, Mark S. Ladinsky, Son-Jong Hwang, Yumei Guo, Qiyun Zhu, Jessica A. Griffiths, Rob Knight, Pamela J. Bjorkman, Mikhail G. Shapiro, Daniel H. Geschwind, Daniel P. Holschneider, Michael A. Fischbach & Sarkis K. Mazmanian
February 14, 2022
Commentary: Targeting microbial metabolites to treat autism
Rochellys Diaz Heijtz, Pierre Gressens & Jonathan R. Swann
March 1, 2021
Plasma and Fecal Metabolite Profiles in Autism Spectrum Disorder
Brittany D Needham, Mark D Adame, Gloria Serena, Destanie R Rose, Gregory M Preston, Mary C Conrad, A Stewart Campbell, David H Donabedian, Alessio Fasano, Paul Ashwood, Sarkis K Mazmanian
October 16, 2020
Gut microbial molecules in behavioural and neurodegenerative conditions
Brittany D Needham, Rima Kaddurah-Daouk, Sarkis K Mazmanian
February 11, 2020
A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice
Timothy R Sampson, Collin Challis, Neha Jain, Anastasiya Moiseyenko, Mark S Ladinsky, Gauri G Shastri, Taren Thron, Brittany D Needham, Istvan Horvath, Justine W Debelius, Stefan Janssen, Rob Knight, Pernilla Wittung-Stafshede, Viviana Gradinaru, Matthew Chapman, Sarkis K Mazmanian
May 13, 2015
Control of brain development, function, and behavior by the microbiome
Timothy R Sampson, Sarkis K Mazmanian
May 13, 2015
The Central Nervous System and the Gut Microbiome
Gil Sharon, Timothy R Sampson, Daniel H Geschwind, Sarkis K Mazmanian
December 19, 2013
Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders
Elaine Y Hsiao, Sara W McBride, Sophia Hsien, Gil Sharon, Embriette R Hyde, Tyler McCue, Julian A Codelli, Janet Chow, Sarah E Reisman, Joseph F Petrosino, Paul H Patterson, Sarkis K Mazmanian
